According to a new study published by the journal Cannabis and Cannabinoid Research, and published online by the U.S. National Institute of Health, cannabis can cause the death of colon cancer cells, implying that it may be a potential treatment option for the disease.
“Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide”, begins the abstract of the study. “Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. However, the active compounds from Cannabis sativa flowers and their interactions remain elusive.” This study was “aimed to specify the cytotoxic effect of C. sativa-derived extracts on colon cancer cells and adenomatous polyps by identification of active compound(s) and characterization of their interaction.”
For the study, ethanol extracts of C. sativa were “analyzed by high-performance liquid chromatography and gas chromatograph/mass spectrometry and their cytotoxic activity was determined using alamarBlue-based assay (Resazurin) and tetrazolium dye-based assay (XTT) on cancer and normal colon cell lines and on dysplastic adenomatous polyp cells.”
Researchers found that “The unheated cannabis extracts (C2F), fraction 7 (F7), and fraction 3 (F3) had cytotoxic activity on colon cancer cells”. Moreover, the extracts induced cell death of polyp cells.”
The study concludes by stating that “C. sativa compounds interact synergistically for cytotoxic activity against colon cancer cells and induce cell cycle arrest, apoptotic cell death, and distinct gene expression”. The study’s results suggest “possible future therapeutic value.”
The full study can be found by clicking here.
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